5-MTHF is the most biologically active form of the B-vitamin folic acid. 5MTHF
works in concert with vitamin B12 (methylcobalamin) in the conversion of
homocysteine to methionine, which provides methyl groups for numerous
other biochemical reactions in the body. Because of this, folate supplementation
supports cardiovascular health, nervous system function, normal cellular proliferation,
and gingival health. Folate supplementation during pregnancy has been shown to
reduce the risk of neural tube defects.
Research has shown a subset of individuals do not efficiently convert folic acid from
the diet or supplements to active 5-MTHF, due to genetic enzyme deficiencies.
Research suggests 5-MTHF is a more efficient form of supplementation than inactive
folic acid in these and other individuals.
Each Capsule Contains
Folate (as 5-methyl-tetrahydrofolate) 1000 mcg
Microcrystalline Cellulose, Hypromellose (derived from cellulose) capsule, Leucine,
*This product uses Gnosis S.p.A.'s L-5-Methyltetrahydrofolate (Extrafolate-SŪ).
Extrafolate-S is a registered trademark of Gnosis S.p.A.
Suggested Use: Take 1 capsule two to three times daily or as recommended by a
This product is contraindicated in an individual with a history of hypersensitivity to
any of its ingredients.
This product does not contain wheat, gluten, corn, yeast, soy, egg, dairy products,
or artificial colors, artificial sweeteners, or artificial flavors. This product also does
not contain lactose, palmitic acid, magnesium stearate, or stearic acid.
If pregnant, consult your health-care practitioner before using this product.
5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrent
with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic
activity; however, this folate source has not been shown to interfere with the anti-
inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis
or rheumatoid arthritis can safely take a supplement containing folate.
Read Dr. Wright's article on folate