This is a high dose 5mg (5000mcg) folate product.
Folic acid must be converted to its active forms to be used by the body.* This is a
multi-step biochemical process that occurs in the intestines and liver. In the presence
of intestinal or liver dysfunction this conversion may not occur sufficiently enough
to meet the body's needs. Furthermore, up to 60-percent of the U.S. population may
have a genetic enzyme defect that makes it difficult for them to convert folic acid into
active 5-MTHF. For these individuals and many others, 5-MTHF supplementation
may be a more effective method of folate repletion.*
5-MTHF is an essential cofactor in the metabolism of the amino acid metabolite
homocysteine. 5-MTHF also must be present in sufficient quantity for normal production
of the neurotransmitters serotonin, melatonin, dopamine, epinephrine, and
norepinephrine. These functions make 5-MTHF critical for both cardiovascular
function and mood support
One Capsule Contains:
Folate (as L-5-Methyltetrahydrofolate*) 5 mg.
Microcrystalline Cellulose, Hypromellose (derived from cellulose) capsule, Leucine,
*This product uses Gnosis S.p.A.'s L-5-Methyltetrahydrofolate (Extrafolate-SŪ).
Extrafolate-S is a registered trademark of Gnosis S.p.A.
Take 1 capsule two to three times daily or as recommended by a health-care
5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrent
with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic
activity; however, this folate source has not been shown to interfere with the anti-
inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis
or rheumatoid arthritis can safely take a supplement containing folate.
*This statement has not been evaluated by the FDA.This product is not intended to
diagnose, treat, cure, or prevent any disease.